APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Abstract ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg
Format:	Article
Language:	English
Published:	BMC 2022-09-01
Subjects:	Apolipoprotein E Neuroinflammation Alzheimer’s disease Neurodegeneration
Online Access:	https://doi.org/10.1186/s13024-022-00566-4