Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons

In vitro generation of motor neurons (MNs) is a promising approach for modeling motor neuron diseases (MNDs) such as amyotrophic lateral sclerosis (ALS). As aging is a leading risk factor for the development of neurodegeneration, it is important to recapitulate age-related characteristics by using M...

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发表在:	Frontiers in Molecular Neuroscience
Main Authors:	Yu Tang, Meng-Lu Liu, Tong Zang, Chun-Li Zhang
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2017-11-01
主题:	human iPSC neural progenitor cells motor neuron ALS direct reprogramming aging
在线阅读:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00359/full