Gene expression of tight junctions in foreskin is not affected by HIV pre-exposure prophylaxis

IntroductionTight junctions (TJs) serve as permeability filters between the internal and external cellular environment. A large number of proteins have been identified to be localized at the TJs. Due to limitations in tissue collection, TJs in the male genital tract have been understudied.MethodsWe...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Emily L. Webb, Stefan Petkov, Heejin Yun, Laura Else, Limakatso Lebina, Jennifer Serwanga, Azure-Dee A. P. Pillay, Thabiso B. Seiphetlo, Susan Mugaba, Patricia Namubiru, Geoffrey Odoch, Daniel Opoka, Andrew S. Ssemata, Pontiano Kaleebu, Saye Khoo, Neil Martinson, Julie Fox, Clive M. Gray, Carolina Herrera, Francesca Chiodi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	emtricitabine tenofovir pre-exposure prophylaxis PrEP foreskin transcriptomes tight junctions cytokines
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1415475/full