Assessing the causal relationship between CRP, IL-1α, IL-1β, and IL-6 levels and intervertebral disc degeneration: a two-sample Mendelian randomization study

Abstract Growing research has suggested an association between chronic inflammation and Intervertebral disc degeneration (IVDD), but whether there is a causal effect remains unknown. This study adopted two-sample Mendelian randomization (MR) approach to explore the etiological role of chronic inflam...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Xin-an Yan, Erdong Shen, Aiyong Cui, Fengjin Zhou, Yan Zhuang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	Intervertebral disc degeneration Mendelian randomization C-reactive protein (CRP) Iinterleukin (IL)-1 $${\alpha }$$ α IL 1 $${\beta }$$ β IL-6
Online Access:	https://doi.org/10.1038/s41598-024-73205-1