High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability

Abstract Metabolic reprogramming is a hallmark of cancer, with acute myeloid leukemia (AML) being no exception. Mitochondrial function, particularly its role in protecting tumor cells against chemotherapy, is of significant interest in AML chemoresistance. In this study, we identified mitochondrial...

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Bibliographic Details

Published in:	Signal Transduction and Targeted Therapy
Main Authors:	Diego A. Pereira-Martins, Isabel Weinhäuser, Emmanuel Griessinger, Juan L. Coelho-Silva, Douglas R. Silveira, Dominique Sternadt, Ayşegül Erdem, Bruno Kosa L. Duarte, Prodromos Chatzikyriakou, Lynn Quek, Antonio Bruno Alves-Silva, Fabiola Traina, Sara T. Olalla Saad, Jacobien R. Hilberink, Amanda Moreira-Aguiar, Maria L. Salustiano-Bandeira, Marinus M. Lima, Pedro L. Franca-Neto, Marcos A. Bezerra, Nisha K. van der Meer, Emanuele Ammatuna, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa, Antonio R. Lucena-Araujo
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-07-01
Online Access:	https://doi.org/10.1038/s41392-025-02303-x