Pneumococcal Surface Protein A-Hybrid Nanoparticles Protect Mice from Lethal Challenge after Mucosal Immunization Targeting the Lungs

Pneumococcal disease remains a global burden, with current conjugated vaccines offering protection against the common serotype strains. However, there are over 100 serotype strains, and serotype replacement is now being observed, which reduces the effectiveness of the current vaccines. Pneumococcal...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Douglas Borges de Figueiredo, Kan Kaneko, Tasson da Costa Rodrigues, Ronan MacLoughlin, Eliane Namie Miyaji, Imran Saleem, Viviane Maimoni Gonçalves
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	hybrid nanoparticles antigen delivery system <i>Streptococcus pneumoniae</i> vaccine chitosan PLGA
Online Access:	https://www.mdpi.com/1999-4923/14/6/1238