Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders

At present, the neuronal mechanisms underlying the diagnosis of autism spectrum disorder (ASD) have not been established. However, studies from human postmortem ASD brains have consistently revealed disruptions in cerebellar circuitry, specifically reductions in Purkinje cell (PC) number and size. A...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Cheryl Brandenburg, Anthony J. Griswold, Derek J. Van Booven, Michaela B. C. Kilander, Jeannine A. Frei, Michael W. Nestor, Derek M. Dykxhoorn, Margaret A. Pericak-Vance, Gene J. Blatt
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	autism cerebellum purkinje cells extracellular matrix nervous system development cell migration
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2022.944837/full