Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration

Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC are particularly vulnerable to degeneration both with normal aging and in neurodegenerative disorders. Consequences of th...

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الحاوية / القاعدة:	Frontiers in Pharmacology
المؤلفون الرئيسيون:	Andrew K. Evans, Erwin Defensor, Mehrdad Shamloo
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2022-11-01
الموضوعات:	locus coeruleus noradrenaline neuroinflammation oxidative stress neurodegeneration beta-adrenergic
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1030609/full