Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis. Yet, very few small molecule inhibitors of MMP-8 have been identified. We reasoned that the synthetic non-sugar mimetics of glycosaminoglycans...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Shravan Morla, Umesh R. Desai
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Subjects:
matrix metalloproteinases
glycosaminoglycans
small molecule inhibitors
drug discovery
Online Access:https://www.mdpi.com/2218-273X/10/8/1166

Internet

https://www.mdpi.com/2218-273X/10/8/1166

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