The Pseudo-Symmetric <i>N</i>-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation

Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric hydroxyethylamine core and heteroarylcarboxyamide moieties. The simple synthetic pathway furnished nine compounds in a few...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Rosarita D’Orsi, Maria Funicello, Teresa Laurita, Paolo Lupattelli, Federico Berti, Lucia Chiummiento
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	HIV-protease inhibitors pseudo-symmetric core heteroaryl carboxyamides synthesis biological screening modeling
Online Access:	https://www.mdpi.com/2218-273X/11/11/1584