MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells

Abstract Natural killer group 2 member D ligands (NKG2DLs) are expressed as stress response proteins in cancer cells. NKG2DLs induce immune cell activation or tumor escape responses, depending on their expression. Human pancreatic cancer cells, PANC-1, express membrane MHC class I polypeptide-relate...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Hitoshi Toyoda, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe, Yuta Baba, Kohei Tajima, Eiji Funayama, Midori Shida, Yuki Maruyama, Aya Sasaki, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Sei Kobayashi, Atsushi Horiike, Noriko Hida, Takehiko Sambe, Koji Nobe, Satoshi Wada, Hitome Kobayashi, Mayumi Tsuji, Shinichi Kobayashi, Takuya Tsunoda, Yoshifumi Kudo, Yuji Kiuchi, Kiyoshi Yoshimura
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	NKG2DL NKG2D T cell MICB ADAM Pancreatic tumor
Online Access:	https://doi.org/10.1038/s41598-024-73712-1