SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

ABSTRACT The Delta variant of SARS-CoV-2 has caused more severe infections than its previous variants. We studied the host innate immune response to Delta, Alpha, and two earlier variants to map the evolution of the recent ones. Our biochemical and transcriptomic studies in human colon epithelial ce...

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Bibliographic Details
Published in:Microbiology Spectrum
Main Authors: Dixit Tandel, Vishal Sah, Nitesh Kumar Singh, Poojitha Sai Potharaju, Divya Gupta, Sauhard Shrivastava, Divya Tej Sowpati, Krishnan H. Harshan
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Subjects:
SARS-CoV-2
COVID-19
variants
Delta
RLR pathway
innate antiviral
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01604-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01604-22

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