Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures

Many diseases of the central nervous system are age-associated and do not directly result from genetic mutations. These include late-onset neurodegenerative diseases (NDDs), which represent a challenge for biomedical research and drug development due to the impossibility to access to viable human br...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Simona Aversano, Carmen Caiazza, Massimiliano Caiazzo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	cell reprogramming Parkinson’ disease Alzheimer’s disease Huntington’s disease ALS in vitro model
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.1069482/full