The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential <i>dap</i>F Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom. Toxicity, ADME, molecular docking, and in vitro antimicrobial studies of the synthesized compounds were carried out. These compounds displayed...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Antibiotics
المؤلفون الرئيسيون:	Mohd Sayeed Shaikh, Mayura A. Kale, V. Muralidharan, T. Venkatachalam, Syed Sarfaraz Ali, Fahadul Islam, Sharuk L. Khan, Falak A. Siddiqui, Humaira Urmee, Ganesh G. Tapadiya, Sachin A. Dhawale, Long Chiau Ming, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Md. Moklesur Rahman Sarker, Mohd Fahami Nur Azlina
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2022-12-01
الموضوعات:	diaminopimelic acid <i>dap</i>F inhibitors structure-based drug design heterocyclic antibacterial enzyme
الوصول للمادة أونلاين:	https://www.mdpi.com/2079-6382/12/1/47