Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin

Enterotoxigenic Bacteroides fragilis (ETBF) can rapidly secrete an enterotoxin termed B. fragilis toxin (BFT), which is thought to be the only recognized virulence factor in ETBF. ETBF can cause acute diarrhea, inflammatory bowel disease (IBD), colorectal cancer, and breast cancer. BFT is divided in...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yucheng Guo, Zhenlin Ouyang, Wenbo He, Jiaxin Zhang, Qian Qin, Min Jiao, Serge Muyldermans, Fang Zheng, Yurong Wen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	Bacteroides fragilis toxin metalloprotease diagnosis nanobody epitope characterization
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1065274/full