Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling

Chronopharmacology of arterial hypertension impacts the long-term cardiovascular risk of hypertensive subjects. Therefore, clinical and computational studies have proposed optimizing antihypertensive medications’ dosing time (Ta). However, the causes and mechanisms underlying the Ta-dependency antih...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Javiera Cortés-Ríos, Maria Rodriguez-Fernandez
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	chronopharmacology hypertension mathematical modeling blood pressure circadian rhythm valsartan
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1110459/full