Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension

Background: The tricarboxylic (TCA) acid cycle provides the energy needed for regulatory functions in the cardio-renal system. Recently, a genetic defect in the TCA cycle enzyme, fumarase hydratase, altered L-arginine metabolism and exacerbated hypertension in salt-sensitive rats. This study evaluat...

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Bibliographic Details

Published in:	Clinical and Experimental Hypertension
Main Authors:	Osaze Edosuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-08-01
Subjects:	fumarate hypertension l-arginine metabolism redox state tricarboxylic acid cycle
Online Access:	http://dx.doi.org/10.1080/10641963.2021.1916943