SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism that medicated inflammatory response during ischemia and reperfusion (I/R...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Ying Han, Weiju Sun, Di Ren, Jingwen Zhang, Zhibin He, Julia Fedorova, Xiaodong Sun, Fang Han, Ji Li
Format:	Article
Language:	English
Published:	Elsevier 2020-07-01
Subjects:	SIRT1 agonist NLRP3 inflammasome ROS Ischemia/reperfusion
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231720303359