Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. elegans Aging

In this contribution, we describe a multi-omics systems biology study of the metabolic changes that occur during aging in Caenorhabditis elegans. Sampling several time points from young adulthood until early old age, our study covers the full duration of aging and include transcriptomics, and target...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Janna Hastings, Abraham Mains, Bhupinder Virk, Nicolas Rodriguez, Sharlene Murdoch, Juliette Pearce, Sven Bergmann, Nicolas Le Novère, Olivia Casanueva
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-02-01
Subjects:	metabolomics flux balance analysis aging systems biology multi-omics whole genome model
Online Access:	https://www.frontiersin.org/article/10.3389/fmolb.2019.00002/full