Anti-Neuroinflammatory Potential of Drospirenone in A TLR4-Driven In Vitro Model of Neuropathic Pain

Objective: Neuroinflammation plays a crucial role in neuropathic pain, of which toll-like receptor 4 (TLR4) is a key mediator. Virtual screening identified Drospirenone as a potential TLR4 inhibitor. This study aims to evaluate the in vitro effects of Drospirenone on TLR4 signalling in U87-MG astroc...

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Bibliographic Details

Published in:	Cell Journal
Main Authors:	Leila Taheran, Hakimeh Zali, Mohammad Ajoudanian, Mir-Shahram Safari, Samira Rajaei, Zahra Hajimahdi, Ali Dabbagh
Format:	Article
Language:	English
Published:	Royan Institute (ACECR), Tehran 2025-08-01
Subjects:	drospirenone drug repurposing neuropathic pain toll-like receptor 4
Online Access:	https://www.celljournal.org/article_732775_b4265bba5f59bf4e5e26868d294c135d.pdf