Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines

The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrimidine scaffold linked to mono-, di-, and trimethoxy benzylidene moieties through hydrazine linkages. First, in silico docking experiments of the synthesized compounds against Bax, Bcl-2, Caspase-3, Ki...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Eman M. Othman, Amany A. Bekhit, Mohamed A. Anany, Thomas Dandekar, Hanan M. Ragab, Ahmed Wahid
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Subjects:	pyrazolo[3,4-d]pyrimidine anticancer activity apoptosis Ki67
Online Access:	https://www.mdpi.com/1420-3049/26/10/2961