Complex Haplotypes of GSTM1 Gene Deletions Harbor Signatures of a Selective Sweep in East Asian Populations

The deletion of the metabolizing Glutathione S-transferase Mu 1 (GSTM1) gene has been associated with multiple cancers, metabolic and autoimmune disorders, as well as drug response. It is unusually common, with allele frequency reaching up to 75% in some human populations. Such high allele frequency...

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Bibliographic Details

Published in:	G3: Genes, Genomes, Genetics
Main Authors:	M. Saitou, Y. Satta, O. Gokcumen
Format:	Article
Language:	English
Published:	Oxford University Press 2018-09-01
Subjects:	copy number variants structural variation cellular detoxification natural selection soft sweep
Online Access:	http://g3journal.org/lookup/doi/10.1534/g3.118.200462