The Oncometabolite 2-Hydroxyglutarate Is Upregulated in Post-Prostatectomy PSA Recurrence of Prostate Cancer: A Metabolomic Analysis

<b>First-line treatment for localized prostate cancer (PCa) includes radical prostatectomy (RP) for high-risk disease.</b> However, in many cases, patients experience biochemical recurrence (BCR), heralded by rising prostate specific antigen (PSA) levels in the serum. Our goal was to ide...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Dontrel W. Spencer Hairston, Shamira Sridharan-Weaver, Abheek Gandhi, Neelu Batra, Blythe P. Durbin-Johnson, Marc A. Dall’Era, Paramita M. Ghosh
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	PSA localized prostate cancer phospholipids triglycerides tricarboxylic acid cycle 2-hydroxyglutarate
Online Access:	https://www.mdpi.com/1420-3049/30/16/3316