Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice

p53 has been implicated in metabolic regulation, but its role in obesity-induced skeletal muscle insulin resistance remains incompletely understood. This study aimed to determine the functional contribution of skeletal muscle p53 to insulin resistance and mitochondrial dysfunction, particularly in t...

Full description

Bibliographic Details

Published in:	Redox Biology
Main Authors:	Soyoung Park, Jin Ki Jung, Jung-Yoon Heo, Themis Thoudam, Su-Yeon Jeong, Seok-Hui Kang, Chang-Hoon Woo, Hyoung Chul Choi, In-kyu Lee, Jinmyoung Dan, Jongsoon Lee, Jae-Ryong Kim, So-Young Park
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	p53 Skeletal muscle Mitochondria-associated membrane Insulin resistance Obesity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725003416