RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

Abstract Background Current antiretroviral therapy is effective in controlling HIV-1 infection. However, cessation of therapy is associated with rapid return of viremia from the viral reservoir. Eradicating the HIV-1 reservoir has proven difficult with the limited success of latency reactivation str...

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Bibliographic Details

Published in:	Retrovirology
Main Authors:	Catalina Méndez, Scott Ledger, Kathy Petoumenos, Chantelle Ahlenstiel, Anthony D. Kelleher
Format:	Article
Language:	English
Published:	BMC 2018-10-01
Subjects:	HIV-1 Latency Reactivation Latent reservoir Epigenetic silencing Transcriptional gene silencing
Online Access:	http://link.springer.com/article/10.1186/s12977-018-0451-0