Early mucosal responses following a randomised controlled human inhaled infection with attenuated Mycobacterium bovis BCG

Abstract The development of an effective vaccine against Mycobacterium tuberculosis is hampered by an incomplete understanding of immunoprotective mechanisms. We utilise an aerosol human challenge model using attenuated Mycobacterium bovis BCG, in BCG-naïve UK adults. The primary endpoint of this st...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Julia L. Marshall, Iman Satti, Mirvat Surakhy, Stephanie A. Harris, Hazel Morrison, Rachel E. Wittenberg, Marco Polo Peralta Alvarez, Shuailin Li, Raquel Lopez Ramon, Emily Hoogkamer, Francsico Javier Salguero, Fernando Ramos Lopez, Celia Mitton, Ingrid Cabrera Puig, Rebecca Powell Doherty, Rachel Tanner, Timothy S. C. Hinks, Henry Bettinson, Helen McShane
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41467-025-60285-4