E3 ubiquitin ligase gene BIRC3 modulates TNF-induced cell death pathways and promotes aberrant proliferation in rheumatoid arthritis fibroblast-like synoviocytes

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovitis, degradation of articular cartilage, and bone destruction. Fibroblast-like synoviocytes (FLS) play a central role in RA, producing a significant amount of inflammatory mediators such as tumor necrosis f...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Qingliang Meng, Kai Wei, Yu Shan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	BIRC3/cIAP2 tumor necrosis factor rheumatoid arthritis ubiquitination MAPK/NF-κB
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1433898/full