Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Glioblastoma is one of the most common and aggressive forms of brain tumor, a rare disease for which there is a great need for innovative therapies. ONC201, a new drug substance, has been used in a compassionate treatment program where the choice of dosage form and regimen have yet to be justified....

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Maxime Annereau, Marina Vignes, Lucas Denis, André Rieutord, François-Xavier Legrand, François Rioblanc, Muriel Paul, Jacques Grill, Philippe-Henri Secretan, Bernard Do
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Subjects:	ONC201 oxidation mechanism photolysis mechanism DFT antioxidant effects preformulation studies
Online Access:	https://www.mdpi.com/1999-4923/15/10/2371