Production of Antigen-Specific Human Monoclonal Antibodies: Comparison of Mice Carrying IgH/κ or IgH/κ/λ Transloci

Here we compare human monoclonal antibody (MAb) production from mouse strains that carry disruptions of their endogenous mouse IgH/Igκ loci and harbor human IgM + Igκ (BABκ) or human IgM + Igκ + Igλ transloci (BABκ,λ). We found that whereas both strains proved effective for the isolation of antigen-...

Full description

Bibliographic Details

Published in:	BioTechniques
Main Authors:	S. Magadán, M. Valladares, E. Suarez, I. Sanjuán, A. Molina, C. Ayling, S.L. Davies, X. Zou, G.T. Williams, M.S. Neuberger, M. Brüggemann, F. Gambón, F. Díaz-Espada, A. González-Fernández
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2002-09-01
Online Access:	https://www.future-science.com/doi/10.2144/02333dd04