Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

Irisin, a myokine secreted by muscle during physical exercise, is known to have biological activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Shuangshuo Jia, Yue Yang, Yishu Bai, Yingliang Wei, He Zhang, Yicheng Tian, Jiabao Liu, Lunhao Bai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Subjects:	irisin osteoarthritis exercise PI3K/Akt/NF-κB pyroptosis chondrocyte
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.797855/full