Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

Irisin, a myokine secreted by muscle during physical exercise, is known to have biological activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Frontiers in Cell and Developmental Biology
المؤلفون الرئيسيون:	Shuangshuo Jia, Yue Yang, Yishu Bai, Yingliang Wei, He Zhang, Yicheng Tian, Jiabao Liu, Lunhao Bai
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2022-03-01
الموضوعات:	irisin osteoarthritis exercise PI3K/Akt/NF-κB pyroptosis chondrocyte
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fcell.2022.797855/full

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