HLA class, calcineurin inhibitor levels, and the risk of graft failure in kidney recipients with de novo donor-specific antibodies

IntroductionDe novo donor-specific HLA antibody (dnDSA) are associated with poor outcomes. Whether this observation applies to both HLA class I and II dnDSA remains unclear.MethodsWe studied 1236 consecutive kidney recipients who had routine anti-HLA antibody surveillance post-transplant.ResultsDuri...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Marc-Antoine Béland, Isabelle Lapointe, Isabelle Côté, Julie Lesage, Isabelle Houde, Eric Wagner, Julie Riopel, Eva Latulippe, Olivier Désy, Sacha A. De Serres
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	donor-specific alloantibodies kidney transplantation anti-HLA alloantibodies graft loss HLA class 1
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493878/full