Molecular interactions between complement factor H and its heparin and heparan sulphate ligands

Complement Factor H (CFH) is the major regulator of the central complement protein C3b in the alternative pathway of complement activation. A molecular view of the CFH interaction with native heparan sulphate is central for understanding the mechanism for how surface-bound CFH interacts with C3b bou...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Stephen John Perkins, Ka Wai eFung, Sanaullah eKhan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-03-01
Subjects:	Complement Factor H Heparin Surface Plasmon Resonance X-ray scattering analytical ultracentrifugation heparan sulphate
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00126/full