Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis

The innate immune DNA sensing cGAS-STING signaling pathway has been widely recognized for inducing interferons (IFNs) and subsequent antiviral state. In addition to IFN, the cGAS-STING pathway also elicits other cell autonomous immunity events including autophagy and apoptosis. However, the downstre...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Nengwen Xia, Wanglong Zheng, Sen Jiang, Qi Cao, Jia Luo, Jiajia Zhang, Yulin Xu, Shaohua Sun, Kaili Zhang, Nanhua Chen, François Meurens, Jianzhong Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	cGAS-STING pathway porcine interferon autophagy apoptosis regulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021384/full