Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage response; however, selective small molecule in...

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Bibliographic Details

Published in:	eLife
Main Authors:	Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-03-01
Subjects:	inhibitor Bloom syndrome RECQ Helicase DNA repair allosteric
Online Access:	https://elifesciences.org/articles/65339