The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

The linear ubiquitin chain assembly complex (LUBAC) is the only known ubiquitin ligase for linear/Met1-linked ubiquitin chain formation. One of the LUBAC components, heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L), was recently shown to catalyse oxyester bond formation between ubiquitin and some sub...

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Bibliographic Details

Published in:	eLife
Main Authors:	Alan Rodriguez Carvajal, Irina Grishkovskaya, Carlos Gomez Diaz, Antonia Vogel, Adar Sonn-Segev, Manish S Kushwah, Katrin Schodl, Luiza Deszcz, Zsuzsanna Orban-Nemeth, Shinji Sakamoto, Karl Mechtler, Philipp Kukura, Tim Clausen, David Haselbach, Fumiyo Ikeda
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-06-01
Subjects:	E3 ubiquitin ligase HOIL-1L oxyester-bond linkage RBR ubiquitin
Online Access:	https://elifesciences.org/articles/60660