Deep learning-driven fragment ion series classification enables highly precise and sensitive de novo peptide sequencing

Abstract Unlike for DNA and RNA, accurate and high-throughput sequencing methods for proteins are lacking, hindering the utility of proteomics in applications where the sequences are unknown including variant calling, neoepitope identification, and metaproteomics. We introduce Spectralis, a de novo...

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发表在:	Nature Communications
Main Authors:	Daniela Klaproth-Andrade, Johannes Hingerl, Yanik Bruns, Nicholas H. Smith, Jakob Träuble, Mathias Wilhelm, Julien Gagneur
格式:	文件
语言:	英语
出版:	Nature Portfolio 2024-01-01
在线阅读:	https://doi.org/10.1038/s41467-023-44323-7