Extracellular spermidine attenuates tryptophan breakdown in mitogen-stimulated peripheral human mononuclear blood cells

Polyamines, particularly spermidine, play a vital role in regulating cellular functions and influencing processes such as proliferation, ageing, and immune modulation. This study explores the effects of spermidine on the immunoregulatory pathway of tryptophan breakdown, which is mediated by indoleam...

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Bibliographic Details

Published in:	Pteridines
Main Authors:	Karg Cornelia A., Lisandrelli Rebecca, Schider Günther, Monfort-Lanzas Pablo, Siller Anita, Schennach Harald, Moser Simone, Fuchs Dietmar, Gostner Johanna M.
Format:	Article
Language:	English
Published:	De Gruyter 2025-10-01
Subjects:	spermidine tryptophan indoleamine 2,3-dioxygenase immunoregulation neopterin
Online Access:	https://doi.org/10.1515/pteridines-2025-0054