Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration

Clofazimine (CFZ) is a broad spectrum antimycobacterial agent recommended by the World Health Organization as a first line treatment for leprosy and second line treatment for multidrug resistant tuberculosis. Oral administration of CFZ leads to a red skin pigmentation side effect. Since CFZ is a wea...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Mikhail D. Murashov, Jennifer Diaz-Espinosa, Vernon LaLone, Joel W. Y. Tan, Raluca Laza, Xueding Wang, Kathleen A. Stringer, Gus R. Rosania
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Subjects:	crystal-like drug inclusion (CLDI) micronized crystals jet milling/micronization drug repurposing CFZ-induced skin pigmentation adverse drug reaction (ADR) macrophages
Online Access:	https://www.mdpi.com/1999-4923/10/4/238