Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

Abstract Medulloblastoma (MB) is the most common type of malignant childhood brain tumor. We previously showed that inhibitors of apoptosis proteins (IAP) small‐molecule inhibitors (LCL161 or LBW242) combined with chemotherapy have synergistic antiproliferative effects on MB cells. The synergistic a...

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發表在:	Cancer Medicine
Main Authors:	Shu‐Mei Chen, Tzu‐Kang Lin, Yuan‐Yun Tseng, Chiao‐Hui Tu, Tai‐Ngar Lui, Shiang‐Fu Huang, Ling‐Ling Hsieh, Ying‐Ying Li
格式:	Article
語言:	英语
出版:	Wiley 2018-08-01
主題:	cell cycle inhibitors of apoptosis proteins medulloblastoma neddylation p21
在線閱讀:	https://doi.org/10.1002/cam4.1658