The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics

Drug hepatotoxicity assessment is a relevant issue both in the course of drug development as well as in the post marketing phase. The use of human relevant in vitro models in combination with powerful analytical methods (metabolomic analysis) is a promising approach to anticipate, as well as to unde...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Guillermo Quintás, José V. Castell, Marta Moreno-Torres
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Subjects:	metabolomics drug hepatotoxicity mechanisms of hepatotoxicity in vitro HepG2 cells primary hepatocytes
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1155271/full