Renal thrombotic microangiopathy and nephrotic proteinuria induced by intravitreal injection of aflibercept for diabetic macular edema

Abstract Background Vascular endothelial growth factor inhibitors (VEGFIs) are used to treat malignant neoplasms and ocular diseases by inhibiting angiogenesis. Systemic use of VEGFIs has various side effects, including hypertension, proteinuria, and thrombotic microangiopathy, but adverse events du...

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Bibliographic Details

Published in:	BMC Nephrology
Main Authors:	Yawara Kikuchi, Yoshimi Odashima, Kazuhiro Yoshikawa, Tomoyasu Oda, Fumitaka Tanaka, Hiroki Oikawa, Yasushi Ishigaki, Koichi Asahi
Format:	Article
Language:	English
Published:	BMC 2022-10-01
Subjects:	Intravitreal injections Thrombotic microangiopathy Vascular endothelial growth factor inhibitor Aflibercept Diabetic macular edema Diabetic nephropathy
Online Access:	https://doi.org/10.1186/s12882-022-02986-2