Total neoadjuvant therapy in high-risk rectal cancer: organ preservation and survival outcomes in a single-center retrospective cohort

Background: Rectal cancer poses a significant global health burden. Conventional neoadjuvant chemoradiotherapy (nCRT) demonstrates limited efficacy in achieving disease-free survival (DFS) and organ preservation. Total neoadjuvant therapy (TNT), an emerging paradigm integrating systemic chemotherapy...

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Bibliographic Details

Published in:	Therapeutic Advances in Medical Oncology
Main Authors:	Zhiyuan Zhang, Ruiyan Wu, Zhenyu Ke, Fan Xia, Guichao Li, Juefeng Wan, Hui Zhang, Yujia Deng, Zhen Zhang, Yan Wang, Lijun Shen
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-05-01
Online Access:	https://doi.org/10.1177/17588359251332466