Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs

Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance. This reality underscores the need to develop novel drugs with unique mechanisms of action. We recently identified 5-(...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Kiem Vu, Benjamin J. Buckley, Richard S. Bujaroski, Eduardo Blumwald, Michael J. Kelso, Angie Gelli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	amiloride HMA analogs antifungal activity Cryptococcus neoformans MIC
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1101568/full