Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 promote the endocytosis and degradation of FZD receptors to inhibit Wnt signal...

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Bibliographic Details
Published in:eLife
Main Authors: Dong Luo, Jing Zheng, Shuning Lv, Ren Sheng, Maorong Chen, Xi He, Xinjun Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-10-01
Subjects:
Wnt signaling
Frizzled5
Frizzled8
FZD5
FZD8
ZNRF3
Online Access:https://elifesciences.org/articles/103996

Internet

https://elifesciences.org/articles/103996

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