SV-MeCa: an XGBoost-based meta-caller approach for structural variant calling from short-read data

Abstract Background Calling structural variants (SVs), i.e., genomic alterations of $$\ge $$ 50bp, from whole genome short-read data remains challenging, as existing callers are known to lack accuracy and robustness. Therefore, meta-caller approaches combining the results of multiple standalone tool...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	Rudel Christian Nkouamedjo Fankep, Arda Söylev, Anna-Lena Kobiela, Jochen Blom, Corinna Ernst, Susanne Motameny
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Structural variants Variant calling Whole-genome sequencing Meta-caller
Online Access:	https://doi.org/10.1186/s12859-025-06246-6