Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling

AChE and BuChE are druggable targets for the discovery of anti-Alzheimer’s disease drugs, while dual-inhibition of these two targets seems to be more effective. In this study, we synthesised a series of novel isoflavone derivatives based on our hit compound G from in silico high-throughput screening...

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Bibliographic Details

Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Bo Feng, Xinpeng Li, Jie Xia, Song Wu
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-01-01
Subjects:	Alzheimer’s disease isoflavone derivatives AChE/BuChE dual-targeted inhibitor molecular modelling
Online Access:	http://dx.doi.org/10.1080/14756366.2017.1347163