ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice

Abstract Background Prior studies suggested that canonical Activin Receptor II (ActRII) and BMP receptor (BMPR) ligands can have opposing, distinct effects on skeletal muscle depending in part on differential downstream SMAD activation. It was therefore of interest to test ActRII ligands versus BMP...

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Bibliographic Details

Published in:	Skeletal Muscle
Main Authors:	Marc A. Egerman, Yuhong Zhang, Romain Donne, Jianing Xu, Abhilash Gadi, Corissa McEwen, Hunter Salmon, Kun Xiong, Yu Bai, Mary Germino, Kevin Barringer, Yasalp Jimenez, Maria del Pilar Molina-Portela, Tea Shavlakadze, David J. Glass
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Skeletal muscle Muscle differentiation Myostatin GDF8 GDF11 Activin A
Online Access:	https://doi.org/10.1186/s13395-025-00373-7