The Response of the Replication Apparatus to Leading Template Strand Blocks

Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand. Replisomes consist of two functional units, a helicase to unwind DNA and polymerases to synthesize it. T...

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Bibliographic Details
Published in:Cells
Main Authors: Marina A. Bellani, Althaf Shaik, Ishani Majumdar, Chen Ling, Michael M. Seidman
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Subjects:
DNA replication
replisome
CMG structure
DNA replication stress
Online Access:https://www.mdpi.com/2073-4409/12/22/2607

Internet

https://www.mdpi.com/2073-4409/12/22/2607

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