PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

ABSTRACT The PI3K/AKT/mTOR signaling axis is a pivotal regulator of key cellular functions, including proliferation, metabolism, survival, and immune modulation. In cancer, its dysregulation drives malignant transformation, tumor progression, therapeutic resistance, and immune evasion. Despite numer...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Subjects:	cancer therapy chemotherapy and immunotherapy drug delivery molecular pathway PI3K/AKT/mTOR axis
Online Access:	https://doi.org/10.1002/mco2.70295